Since the release of Resident Evil 2 in 1998, Mr. X also made an appearance in the 2009 game Resident Evil: The Darkside Chronicles.
On December 4th, 2018, Resident Evil YouTube channel released a three-minute gameplay video showing Mr. X chases main characters Leon Kennedy and Claire Redfield through the game locations. Akin to the original game, on numerous occasions Mr. X appears as a bald grey-skinned individual of extremely large proportions, dressed in a trenchcoat and a fedora. In the novel, Claire Redfield often refers to T-00 as 'Mr. X' presumably originates from Resident Evil: City of the Dead novelization of the game first published on August 3rd, 1999. Kennedy and Claire Redfield encounter the menacing superhuman boss character T-00, who continuously stalks them through the game locations with the intent to eliminate them. On multiple occasions during the game, main protagonists Leon S.
On January 21st, 1998, the survival horror game Resident Evil 2 ( Biohazard 2 in Japan) was released for the original PlayStation game console.